Engineering a Protein Scaffold from a PHD Finger
نویسندگان
چکیده
منابع مشابه
Evolution of three-finger toxins - a versatile mini protein scaffold.
Among snake venom toxins, three-finger toxins - a superfamily of nonenzymatic proteins - are found in the venoms of all families of snakes. They share a common structure of three β-stranded loops extending from a central core containing all four conserved disulfide bonds. Despite the similar structural fold, they exhibit a wide variety of biological effects. This review describes briefly the st...
متن کاملThe albumin-binding domain as a scaffold for protein engineering
The albumin-binding domain is a small, three-helical protein domain found in various surface proteins expressed by gram-positive bacteria. Albumin binding is important in bacterial pathogenesis and several homologous domains have been identified. Such albumin-binding regions have been used for protein purification or immobilization. Moreover, improvement of the pharmacokinetics, through the non...
متن کاملf/sla from learner perspectives: a social activity or a cognitive process
in the past couple of decades sociocultural theory of sla and its implications in efl contexts have attracted attentions of research circles worldwide and aroused some controversies. firth and wagner (1997) have questioned the principles of the cognitive view which gives importance to mental constructs in favor of sociocultural view which highlights social and contextual constructs. but if soci...
15 صفحه اولThe PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor
Phosphoinositides (PtdInsPs) play critical roles in cytoplasmic signal transduction pathways. However, their functions in the nucleus are unclear, as specific nuclear receptors for PtdInsPs have not been identified. Here, we show that ING2, a candidate tumor suppressor protein, is a nuclear PtdInsP receptor. ING2 contains a plant homeodomain (PHD) finger, a motif common to many chromatin-regula...
متن کاملA PHD finger protein involved in both the vernalization and photoperiod pathways in Arabidopsis.
The proper timing of flowering is critical for successful reproduction. The perception of the seasonal cues of day-length changes and exposure to cold influences flowering time in many plant species through the photoperiod and vernalization pathways, respectively. Here we show that a plant homeodomain (PHD) finger-containing protein, VIN3-LIKE 1 (VIL1), participates in both the photoperiod and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Structure
سال: 2003
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(03)00122-9