Engineering the variable region of therapeutic IgG antibodies
نویسندگان
چکیده
منابع مشابه
Variable region domain exchange influences the functional properties of IgG.
In the present study we have characterized a family of anti-dansyl Abs with the variable region of the heavy chain on human Ckappa and the variable region of the light chain on different human gamma constant regions (creating inside-out molecules). Although fully assembled molecules were secreted, this variable region exchange slowed the kinetics of Ab assembly. Although the variable region exc...
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ژورنال
عنوان ژورنال: mAbs
سال: 2011
ISSN: 1942-0862,1942-0870
DOI: 10.4161/mabs.3.3.15234