Enhancement of poly(orthoester) microspheres for DNA vaccine delivery by blending with poly(ethylenimine)
نویسندگان
چکیده
منابع مشابه
An Endogenous Immune Adjuvant Released by Necrotic Cells for Enhancement of DNA Vaccine Potency
Background: Improving vaccine potency in the induction of a strong cell-mediated cytotoxicity can enhance the efficacy of vaccines. Necrotic cells and the supernatant of necrotic tumor cells are attractive adjuvants, on account of their ability to recruit antigen-presenting cells to the site of antigen synthesis as well as its ability to stimulate the maturation of dendritic cells. Objective: T...
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The recent advances in controlled delivery systems for protein pharmaceuticals such as microspheres, liposomes, pumps and implants, have provided a new avenue for delivery of vaccine antigens. Adjuvants aimed at increasing the immunogenicity of recombinant antigens remain a focus in vaccine development worldwide, there is currently considerable care for the development of chitosan microspheres ...
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Cell surface-bound receptors represent suitable entry sites for gene delivery into cells by receptor-mediated endocytosis. Here we have taken advantage of the mannose receptor that is highly expressed on antigen-presenting dendritic cells for targeted gene transfer by employing mannosylpolyethylenimine (ManPEI) conjugates. Several ManPEI conjugates were synthesized and used for formation of Man...
متن کاملan endogenous immune adjuvant released by necrotic cells for enhancement of dna vaccine potency
background: improving vaccine potency in the induction of a strong cell-mediated cytotoxicity can enhance the efficacy of vaccines. necrotic cells and the supernatant of necrotic tumor cells are attractive adjuvants, on account of their ability to recruit antigen-presenting cells to the site of antigen synthesis as well as its ability to stimulate the maturation of dendritic cells. objective: t...
متن کاملCrosslinked linear polyethylenimine enhances delivery of DNA to the cytoplasm.
Crosslinked polyethylenimines (PEIs) have been frequently examined over the past decade since they can maintain the transfection efficiency of commercially available, 25k branched PEI, but exhibit less cytotoxicity. The argument is often made that the degradability of such polymers, generally synthesized with either disulfide or hydrolytically degradable crosslinkers, is critical to the high ef...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2008
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2008.03.011