Enhancing developmental rate and quality of mouse single blastomeres into blastocysts using a microplatform
نویسندگان
چکیده
منابع مشابه
Developmental Bias in Cleavage-Stage Mouse Blastomeres
BACKGROUND The cleavage-stage mouse embryo is composed of superficially equivalent blastomeres that will generate both the embryonic inner cell mass (ICM) and the supportive trophectoderm (TE). However, it remains unsettled whether the contribution of each blastomere to these two lineages can be accounted for by chance. Addressing the question of blastomere cell fate may be of practical importa...
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چکیده ندارد.
Developmental fate and lineage commitment of singled mouse blastomeres.
The inside-outside model has been invoked to explain cell-fate specification of the pre-implantation mammalian embryo. Here, we investigate whether cell-cell interaction can influence the fate specification of embryonic blastomeres by sequentially separating the blastomeres in two-cell stage mouse embryos and continuing separation after each cell division throughout pre-implantation development...
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It is well known that oocytes can reprogram differentiated cells, allowing animal cloning by nuclear transfer. We have recently shown that fertilized zygotes retain reprogramming activities, suggesting that such activities might also persist in cleavage-stage embryos. Here, we used chromosome transplantation techniques to investigate whether the blastomeres of two-cell-stage mouse embryos can r...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2018
ISSN: 0021-9541,1097-4652
DOI: 10.1002/jcp.26879