Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics
نویسندگان
چکیده
منابع مشابه
Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics
The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are available for their chemical macrocyclization, however, enzyme-mediated methods remain of great interest in terms of synthetic utility. To date, known macrocyclization enzymes have been shown to be active on both peptide and protein substr...
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Natural products comprise a diverse array of molecules, many of which are biologically active. Most natural products are derived from combinations of polyketides, peptides, sugars, and fatty-acid building blocks. Peptidic macrocycles have attracted attention as potential therapeutics possessing cell permeability, stability, and easy-to-control variability. Here, we show that enzymes from the pa...
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Peptide macrocycles have found applications that range from drug discovery to nanomaterials. These ring-shaped molecules have shown remarkable capacity for functional fine-tuning. Such capacity is enabled by the possibility of adjusting the peptide conformation using the techniques of chemical synthesis. Cyclic peptides have been difficult, and often impossible, to prepare using traditional syn...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2016
ISSN: 1433-7851
DOI: 10.1002/anie.201601564