Enzyme‐like Supramolecular Iridium Catalysis Enabling C−H Bond Borylation of Pyridines with <i>meta</i> ‐Selectivity

The use of secondary interactions between substrates and catalysts is a promising strategy to discover selective transition metal for atom-economy C−H bond functionalization. most powerful are found via trial-and-error screening due the low association constants substrate catalyst in which small stereo-electronic modifications within them can lead very different reactivities. To circumvent these limitations increase level reactivity prediction important reactions, we report herein supramolecular harnessing Zn⋅⋅⋅N that binds pyridine-like as tight it be some enzymes. distance spatial geometry active site binding ideal target unprecedented meta-selective iridium-catalyzed borylations with enzymatic Michaelis–Menten kinetics, besides unique selectivity dormant patterns.