Eperisone

Eperisone hydrochloride-induced maculopapular rash

Here, we report a case of a 30-year-old male who was prescribed eperisone hydrochloride for body pain and loose stools after which he developed severe maculopapular rash. Eperisone hydrochloride is an analgesic and antispastic drug used for spastic diseases such as spastic paralysis in cerebrovascular diseases, cervical spondylosis, and periarthritis. The drug is marketed in most of the Asian c...

A case of eperisone hydrochloride-induced anaphylaxis: A true type I reaction?

Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study.

Eperisone hydrochloride (4'-ethyl-2-methyl-3-piperidinopropiophenone hydrochloride) is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. The aim of this research was to investigate the efficacy of eperisone in patients with acute low back pain and spasticity of spinal muscles. The study design was a randomized, double-blind (double-dummy) study in 1...

A sensitive liquid chromatography–electrospray ionization-mass spectrometry (LC–ESI-MS) method for determination of eperisone

spectrometry (LC–ESI-MS) method for determination of eperisone in human plasma using buflomedil as the internal standard (IS) is established. After being made alkaline with saturated sodium bicarbonate solution, plasma samples are extracted with a mixture of diethyl ether–cyclohexane (1:1, v/v) and separated by highperformance liquid chromatography on a reversed-phase C1 8 column with a mobile ...

Effects of Two Different Doses of Eperisone in the Treatment of Acute Low Back Pain

Objectives: to evaluate efficacy and tolerability of two different dosages of eperisone (150 and 300 mg/day) in comparison with those of diazepam 15 mg/day, orally given for seven days. Methods: Spontaneous and provoked pain, muscular contracture and its impact on working capacity as well as “hand-to-floor” distance and degree of lumbar tract flexion were assessed in a randomised double-blind t...