Epidemiological Studies: A Practical Guide.

Meta-analysis of data from animal studies: A practical guide

Meta-analyses of data from human studies are invaluable resources in the life sciences and the methods to conduct these are well documented. Similarly there are a number of benefits in conducting meta-analyses on data from animal studies; they can be used to inform clinical trial design, or to try and explain discrepancies between preclinical and clinical trial results. However there are inheri...

A practical guide for pharmacists

Uncertainty Analysis A practical guide

During the DELPHI project a first attempt was made to standard-ise the way uncertainty analysis was carried out. However, some of the documents that were produced contain errors w.r.t. the treatment of systematic errors and could easily lead to a misinterpretation of the underlying theory. Therefore Philips Research and CQM decided to produce a document that deals with this subject in a more pr...

Mammalian RNAi: a practical guide.

Silencing of gene expression by RNA interference (RNAi) has become a powerful tool for the functional annotation of the Caenorhabditis elegans and Drosophila melanogaster genomes. Recent advances in the design and delivery of targeting molecules now permit efficient and highly specific gene silencing in mammalian systems as well. RNAi offers a simple, fast, and cost-effective alternative to exi...

Information synthesis: a practical guide.

Information synthesis is one of the most valuable contributions a scientist can make. This paper offers guidance in preparing information synthesis and a means of assessing their adequacy. Preparing an information synthesis requires four steps: defining the topic and relevant information about that topic, the purpose of the synthesis, and the target audience; systematically gathering this relev...