Epidermal growth factor (hEGF) has no effect on murine intestine epithelial damage and regeneration after melphalan
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Enhancement of epidermal regeneration by biosynthetic epidermal growth factor
Epidermal regeneration depends on mitosis and migration of keratinocytes. Epidermal growth factor is known to stimulate growth of keratinocytes in vitro, thus it might be expected to promote wound healing. The results of this study show that topical application of biosynthetic human epidermal growth factor accelerates epidermal regeneration in split-thickness wounds and partial-thickness burns....
متن کاملRecombinant human epidermal growth factor (rhEGF) protects radiation-induced intestine injury in murine system.
This study was to investigate whether rhEGF protects radiation induced intestine injury without compromising antitumor effect of radiation in murine system. A radiation induced intestinal injury model was established in mice by whole body irradiation. Using this model, 4 groups were set; control, rhEGF (100 µg/kg intraperitoneally), radiation (10 Gy), and a combination (rhEGF and radiation). Th...
متن کاملKinetics of corneal epithelial regeneration. II. Epidermal growth factor and topical corticosteroids.
The kinetics of rabbit corneal epithelium regeneration were studied to determine if topical corticosteroid has an adverse effect on corneal epithelial wound healing, and if epidermal growth factor (EGF) can abrogate any adverse effect of topical corticosteroid. Healing of standardized 7 mm. central corneal epithelial wounds was determined by serial standardized color photography of the flouresc...
متن کاملThe Periplasmic Expression of Recombinant Human Epidermal Growth Factor (hEGF) in Escherichia coli
Expression of recombinant eukaryotic proteins in Escherichia coli often results in the formation of inclusion bodies. In the case of disulfide-bonded proteins such as hEGF, inclusion body formation can be anticipated if the protein is produced in the bacterial cytosol. The consequence is improper folding which results in aggregation. Proper folding and solubility of such protein are pre-requisi...
متن کاملConstruction of Yeast Recombinant Expression Vector Containing Human Epidermal Growth Factor (hEGF).
PURPOSE The objective of this study was construction of recombinant hEGF-pPIC9 which may be used for expression of recombinant hEGF in following studies. METHODS EGF cDNA was purchased from Genecopoeia Company and used for PCR amplification. Prior to ligation, the PCR product and pPIC9 vector was digested with EcoRI and XhoI and ligated in pPIC9 vector and subjected to colony PCR screening an...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1985
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1985.251