Epidermal growth factor receptor overexpression/amplification in adenocarcinomas arising in the gastrointestinal tract
نویسندگان
چکیده
منابع مشابه
Epidermal growth factor receptor overexpression/amplification in adenocarcinomas arising in the gastrointestinal tract.
INTRODUCTION it has been suggested that EGFR might be valuable to select patients for immunotherapy for various types of cancers. AIMS we investigated: a) the gene/proteins alterations in gastrointestinal cancers using immunohistochemistry (IHC) (gene overexpression) and fluorescence in situ hybridisation (FISH) (gene amplification); and b) the associations between EGFR overexpression and amp...
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Objective(s): Our previous study showed that a newly designed tracer radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline ([125I]PYK) is promising for the evaluation of the epidermal growth factor receptor (EGFR) status and prediction of gefitinib treatment of non-small cell lung cancer. EGFR is over-expressed and mutated also in glioblastoma. In the present study, the ...
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BACKGROUND Epidermal growth factor receptor (EGFR) gene mutations are frequently found in pulmonary adenocarcinomas. MATERIALS AND METHODS Various lung cancers (n=30) including 8 small adenocarcinomas were examined for EGFR gene mutations in three exons. RESULTS Mutations were detected in 32% of adenocarcinomas. Exon 19 mutations were detected in 5 tumors, often advanced stages: 1 in Noguch...
متن کاملassessment of epidermal growth factor receptor status in glioblastomas
objective(s): our previous study showed that a newly designed tracer radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline ([125i]pyk) is promising for the evaluation of the epidermal growth factor receptor (egfr) status and prediction of gefitinib treatment of non-small cell lung cancer. egfr is over-expressed and mutated also in glioblastoma. in the present study,...
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ژورنال
عنوان ژورنال: Revista Española de Enfermedades Digestivas
سال: 2011
ISSN: 1130-0108
DOI: 10.4321/s1130-01082011001200005