Epigenetic gene expression links heart failure to memory impairment
نویسندگان
چکیده
منابع مشابه
Stress, epigenetic control of gene expression and memory formation.
Making memories of a stressful life event is essential for an organism's survival as it allows it to adapt and respond in a more appropriate manner should the situation occur again. However, it may be envisaged that extremely stressful events can lead to formation of traumatic memories that are detrimental to the organism and lead to psychiatric disorders such as post-traumatic stress disorder ...
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Cognitive impairment (CI) is increasingly recognized as a common adverse consequence of heart failure (HF). Although the exact mechanisms remain unclear, microembolism, chronic or intermittent cerebral hypoperfusion, and/or impaired cerebral vessel reactivity that lead to cerebral hypoxia and ischemic brain damage seem to underlie the development of CI in HF. Cognitive decline in HF is characte...
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Tissue inhibitor of matrix metalloprotease 4 (TIMP4) is endogenously one of the key modulators of matrix metalloprotease 9 (MMP9) and we have reported earlier that cardiac specific TIMP4 instigates contractility and helps in differentiation of cardiac progenitor cells. Although studies show that the expression of TIMP4 goes down in heart failure but the mechanism is unknown. This study aims to ...
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A lthough neurohormonal antagonist and device therapies have improved outcomes in patients with systolic heart failure (HF), residual morbidity and mortality remain high. Novel HF therapeutic approaches thus remain an unmet clinical need of pressing urgency. Such approaches depend, in turn, on keener understanding of the molecular pathways underlying HF pathogenesis. Although a number of novel ...
متن کاملGi-biased β2AR signaling links GRK2 upregulation to heart failure.
RATIONALE Phosphorylation of β(2)-adrenergic receptor (β(2)AR) by a family of serine/threonine kinases known as G protein-coupled receptor kinase (GRK) and protein kinase A (PKA) is a critical determinant of cardiac function. Upregulation of G protein-coupled receptor kinase 2 (GRK2) is a well-established causal factor of heart failure, but the underlying mechanism is poorly understood. OBJEC...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2021
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.201911900