Epothilone D affects cell cycle and microtubular pattern in plant cells

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Epothilone D affects cell cycle and microtubular pattern in plant cells.

Epothilones, macrocyclic lactones from culture filtrates of the myxobacterium Sorangium cellulosum, are known as taxol-like microtubular drugs in human medicine. To date, nothing is known about the effect of epothilones on microtubules (MTs) in plant cells and/or on the plant cell cycle. As shown in this report, the treatment of tomato cell suspension cultures with epothilone D produced a conti...

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The plant cell cycle.

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Since their discovery in the soil bacterium Sorangium cellulosum, epothilones have emerged as a valuable substance class with promising anti-tumor activity. Because of their benefits in the treatment of cancer and neurodegenerative diseases, epothilones are targets for drug design and pharmaceutical research. The final step of their biosynthesis - a cytochrome P450 mediated epoxidation of epoth...

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ژورنال

عنوان ژورنال: Journal of Experimental Botany

سال: 2005

ISSN: 1460-2431,0022-0957

DOI: 10.1093/jxb/eri211