ERα-negative and triple negative breast cancer: Molecular features and potential therapeutic approaches
نویسندگان
چکیده
منابع مشابه
[Triple-negative breast cancer: molecular characteristics and potential therapeutic approaches].
The term triple-negative breast cancer (TNBC) defines breast tumors that do not express estrogen receptors, progesterone receptor or epidermal growth factor receptor HER2 on immunohistochemical analysis. TNBC accounts for 12-17% of all types of breast cancer. Molecular profiling indicated that triple-negative breast cancer represents a heterogeneous subgroup of breast cancer. Triple-negative br...
متن کاملClinicopathological Features of Non-metastatic Triple Negative Breast Cancer
Background: Triple negative breast cancer (TNBC) is reported to be associated with a high risk of recurrence, poor overall survival (OS), and disease-free survival (DFS) rates. This study evaluated the clincopathological features and survival of non-metastatic TNBC women in the capital of Iran compared with other areas of the world. Methods: In a retrospective study, 119 women with TNBC based ...
متن کاملTriple-Negative Breast Cancer: Frequency, Molecular Subtypes, and Therapeutic Options
INT RO DUC TI ON Breast cancer is the most common malignancy in women. An estimated 1 million cases of breast cancer are diagnosed annually worldwide and 400.000 patients die from the disease every year[1]. Multiple oncogenes, tumor suppressor genes, and sex steroid hormones and their receptors are involved in the genesis and development of breast cancer. Breast cancer is a heterogeneous malign...
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Triple negative breast cancers (TNBCs) account for 15% of all breast cancers, and represent one of the most aggressive forms of the disease, exhibiting short relapse-free survival. In contrast to other breast cancer subtypes, the absence of knowledge about the etiopathogenic alterations that cause TNBCs force the use of chemotherapeutics to treat these tumors. Because of this, efforts have been...
متن کاملTriple-Negative Breast Cancer: Adjuvant Therapeutic Options
Triple-negative breast cancer (TNBC), a subtype distinguished by negative immunohistochemical assays for expression of the estrogen and progesterone receptors (ER/PR) and human epidermal growth factor receptor-2(HER2) represents 15% of all breast cancers. Patients with TNBC generally experience a more aggressive clinical course with increased risk of disease progression and poorer overall survi...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
سال: 2009
ISSN: 0304-419X
DOI: 10.1016/j.bbcan.2009.06.003