Erratum to: Sustained Released Nifedipine Formulations

Application of nifedipine sustained-release suppositories to healthy volunteers.

poorly water-soluble-carrier, were administered to healthy volunteers, and their sustained-release characteristics, bioavailability and clinical utility were investigated. It was found that D-15 was able to maintain a therapeutically effective level of NF from 30 min to 10 h without causing an excessively high peak level and offered good bioavailability. From the results of pharmacokinetic anal...

Erratum to: Armentum: a hybrid direct search optimization methodology

In the original publication of this article unfortunately the co-authors were omitted. The two co-authors are displayed now.

Erratum

Development of shellac-coated sustained release pellet formulations.

Shellac is an important coating material for food products. Since the introduction of aqueous ammoniacal solutions it also regained importance for pharmaceutical applications. Because of the comparatively high dissolution pH of this material, further additives are required if shellac is used as enteric coating material. However, this dissolution behaviour of shellac may be of interest for susta...

Pharmacokinetic-Pharmacodynamic Model of Newly Developed Dexibuprofen Sustained Release Formulations

Pharmacokinetic-pharmacodynamic (PK-PD) modeling has emerged as a major tool in clinical pharmacology to optimize drug use by designing rational dosage forms and dosage regimes. Quantitative representation of the dose-concentration-response relationship should provide information for the prediction of the level of response to a certain level of drug dose. This paper describes the experimental d...