Estimation of Prothrombin
نویسندگان
چکیده
منابع مشابه
Estimation of Prothrombin in Dicoumarin Therapy.
The concept of prothrombin as the specific precursor of thrombin dates from the so-called classical theory of blood coagulation put forward by Schmidt (1895) and Morawitz (1905). This theory, which considers that four factors, thromboplastin, prothrombin, calcium, and fibrinogen, are concerned in the formation of fibrin, has been the basis of most modern work. The theory was of more academic th...
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Prothrombin, both by a one- and a two-stage method, and progressive antithrombin were determined on the same plasma samples from 47 patients with cirrhosis and 27 patients with acute hepatitis. In the first group prothrombin estimated by the two-stage method was significantly higher than by the one-stage method. The values were often within the normal range and were not correlated with the indi...
متن کاملFrequency Estimation of Prothrombin Allelic Polymorphisms in Indian Population
The study here is to estimate the frequency of Prothrombin allelic polymorphisms from randomly selected general population. Prothrombin is a blood-clotting protein, a vitamin K-dependent clotting factor. The gene has a mutation at position 20210, hence the disorder being referred to as Prothrombin mutation 20210. The PT20210 polymorphisms were identified using simple PCR and followed by Restric...
متن کاملInduction of prothrombin synthesis by prothrombin fragments.
The mechanisms by which blood levels of prothrombin (PT) are regulated in the vitamin K-sufficient state are unknown. We have studied PT synthesis by Reuber H-35 rat hepatoma cells exposed to vitamin K and [3H]leucine in serum-free cultures. Administration to the culture system of exogenous bovine PT and rat PT was characterized by increases in endogenous PT synthesis and secretion of 2- and 3-...
متن کاملNovel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions.
Staphylocoagulase (SC) is a potent nonproteolytic prothrombin (ProT) activator and the prototype of a newly established zymogen activator and adhesion protein family. The staphylocoagulase fragment containing residues 1-325 (SC-(1-325)) represents a new type of nonproteolytic activator with a unique fold consisting of two three-helix bundle domains. The N-terminal, domain 1 of SC (D1, residues ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1942
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.4244.575