Estrogen response element enhances adenovirus-mediated transfer of the p53 gene according to codon 72 polymorphisms and cellular estrogen receptor expression
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چکیده
منابع مشابه
HPV E6 Knockdown Restores Adenovirus Mediated-Estrogen Response Element Linked p53 Gene Transfer in HeLa Cells
p53 is inactivated and degraded by the E6 protein encoded by the integrated human papillomavirus (HPV) in the cervical cancers (Scheffner et al., 1990). The susceptibility of p53 to degradation by the E6 protein varies between the arginine and proline variants at codon 72 of p53 (Storey et al., 1998). In vivo studies demonstrate that the arginine p53 variant is seven times more susceptible to d...
متن کاملAn upstream estrogen response element linked to exogenous p53 tumor suppressor gene expression differentiates effects of the codon 72 polymorphism.
The objective of this study was to assess the effects of an upstream estrogen response element (ERE) on exogenous p53 tumor suppressor gene with a codon 72 polymorphism about which there have been controversial reports in relation to cancer risk. The p53 gene (bases 166-1143 from start codon) with the codon 72 polymorphism, inserted into the pIRES-hrGFP II plasmid with or without upstream ERE, ...
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Backgrounds and Aims: P53 gene is regarded important in pathogenesis of different cancers. Therefore, this study aimed to investigate the frequency of p53 gene codon 72 Arg/Pro polymorphism in women suffering from breast cancer. Materials and Methods: A total of 90 patients with breast cancer and 83 matched healthy control women participated in this case-control study. Genomic DNA was extrac...
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OBJECTIVE Mutated p53 gene is related to the instability of cell growth and cell cycle progression. We aimed to evaluate the association between endometriosis and p53 codon 11, 72 and 248 gene polymorphisms. PATIENTS AND METHODS Women were divided into two groups: (1) moderate/severe endometriosis (n=148), and (2) non-endometriosis groups (n=150). P53 gene polymorphisms include codon11 Glu/Gl...
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Abstract Background: The Iranian breast cancer patients are relatively younger than their Western counterparts. Evidence suggests that alterations in estrogen signaling pathways , including estrogen receptor-α (ER- α ), occur during breast cancer development in Caucasians. Epidemiologic studies have revealed that age-incidence patterns of breast cancer in Asians differ from those in Cauca...
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ژورنال
عنوان ژورنال: journal of Cancer Therapeutics and Research
سال: 2012
ISSN: 2049-7962
DOI: 10.7243/2049-7962-1-31