Estrogen Response Elements Function as Allosteric Modulators of Estrogen Receptor Conformation
نویسندگان
چکیده
منابع مشابه
Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements.
Hormone-activated ERs (ERalpha and ERbeta) bind with high affinity to specific DNA sequences, estrogen response elements (EREs), located within the regulatory regions of target genes. Once considered to function solely as receptor tethers, there is an increasing amount of recent evidence to suggest that the sequence of the ERE can influence receptor activity. In this study, we have performed a ...
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The estrogen receptor (ER) is a ligand-activated enhancer protein that is a member of the steroid/nuclear receptor superfamily. Two genes encode mammalian ER: ERalpha and ERbeta. ER binds to specific DNA sequences called estrogen response elements (EREs) with high affinity and transactivates gene expression in response to estradiol (E(2)). The purpose of this review is to summarize how natural ...
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Virtual high throughput screening (VHTS) was performed to assess possible interactions which might occur between commercially available triphenylphosphonium (TPP) cations and estrogen receptor alpha (ERalpha) that could be exploited to design novel ERalpha modulators. One application of TPP cations is for delivering bioactive molecules to targets in mitochondria as the large membrane potential ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1998
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.18.4.1927