Evaluation of a 3D local multiresolution algorithm for the correction of partial volume effects in positron emission tomography

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Evaluation of a 3D local multiresolution algorithm for the correction of partial volume effects in positron emission tomography.

PURPOSE Partial volume effects (PVEs) are consequences of the limited spatial resolution in emission tomography leading to underestimation of uptake in tissues of size similar to the point spread function (PSF) of the scanner as well as activity spillover between adjacent structures. Among PVE correction methodologies, a voxel-wise mutual multiresolution analysis (MMA) was recently introduced. ...

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Partial volume effects in positron emission tomography (PET) lead to quantitative under- and over-estimations of the regional concentrations of radioactivity in reconstructed images and corresponding errors in derived functional or parametric images. The limited resolution of PET leads to "tissue-fraction" effects, reflecting underlying tissue heterogeneity, and "spillover" effects between regi...

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Quantitative accuracy of positron emission tomography (PET) is decreased by the partial volume effect (PVE). The PVE correction (PVC) methods proposed by Alfano et al., Rousset et al., Müller-Gärtner et al. and Meltzer et al. were evaluated in the present study to obtain guidelines for selecting among them. For accuracy evaluation, the Hoffman brain phantom was scanned with three PETs of differ...

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A Generalized Methodology For Partial Volume Correction In Emission Tomography

We describe a generic methodology to correct 3-D partial volume effects in clinical emission scans. It is based on prior knowledge of tracer biodistribution and tomographic imaging characteristics. We derive this information from registered and segmented MR/CT data. Two fast numerical algorithms are then used to estimate structure-specific recovery coefficients and activity spillover contributi...

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ژورنال

عنوان ژورنال: Medical Physics

سال: 2011

ISSN: 0094-2405

DOI: 10.1118/1.3608907