Evaluation of nephroprotective activity of Tinospora cordifolia against gentamicin induced nephrotoxicity in albino rats: an experimental study
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چکیده
منابع مشابه
Protective Role of Tinospora Cordifolia against Cisplatin- Induced Nephrotoxicity
The importance of Tinospora cordifolia stem extract was investigated for its possible curative effect in male wistar rats against the cisplatin induced nephrotoxicity. Oral administration of plant extract cured the cisplatin induced kidney damage. There was an increase in serum creatinine, blood urea nitrogen and alkaline phosphatase in rats treated with Cisplatin (5mg/kg body weight, i.p). Adm...
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Gentamicin is an important aminoglycoside antibiotic. However its use is limited to serious and life threatening gram negative infections, because of its high nephrotoxicity potential in patients. There are reports that safranal, the active ingredient of saffron with antioxidant properties, exerts protective effect against ischemic injuries occurred by certain nephrotoxins including gentamicin....
متن کاملExperimental Evaluation of Nephroprotective Potential of Calotropis procera (Ait) Flowers against Gentamicin-Induced Toxicity in Albino Rabbits
Received: Revised: Accepted: November 13, 2014 February 12, 2015 February 21, 2015 Gentamicin-induced nephrotoxicity is associated with free radicals generation in kidney tissue. Medicinal plants contain bioactive constituents that act as natural antioxidants, which can protect the biological system from oxidative stress. In this study, phytochemical constituents of aqueous extract of Calotropi...
متن کاملVitamin E protection against gentamicin-induced nephrotoxicity in rats: a biochemical and histopathologic study
The specificity of gentamicin for vitamin E deficiency-associated oxidative stresses in the renal proximal convoluted tubules is apparently related to its ability to increasingly facilitate generation of radical species in mitochondria. To determine the ways in which vitamin E manage the currently processes, we conducted a prospective study aimed to investigate the tubular preserving effect of ...
متن کاملProtective effect of crocin on gentamicin-induced nephrotoxicity in rats
Objective(s): Gentamicin is used for the treatment of Gram-negative bacterial infections. However, gentamicin administration is limited because of nephrotoxicity. The aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats. Materials and Methods: Thirty two male Wistar rats received gentamicin (100 mg/kg, IP), with or without c...
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ژورنال
عنوان ژورنال: International Journal of Basic & Clinical Pharmacology
سال: 2019
ISSN: 2279-0780,2319-2003
DOI: 10.18203/2319-2003.ijbcp20192181