Evaluation of Thermal-Induced Polymorphic Transformation on Desloratadine and Desloratadine-Benzoic Acid Salt
نویسندگان
چکیده
منابع مشابه
Desloratadine Induced Pill Esophagitis
Pill induced esophagitis is a rare complication mostly seen in patients using tetracycline and its derivatives or non-steroidal anti-inflammatory drugs. Here we present a 37 years old female patient experiencing pill esophagitis after taking desloratadine without liquid immediately before going to bed. This was the first pill esophagitis case related with desloratadine reported in the literatur...
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چکیده ندارد.
15 صفحه اولFormulation of Desloratadine Oral Disintegrating Tablets
Article history: Received on: 13/08/2014 Revised on: 09/09/2014 Accepted on: 15/10/2014 Available online: 27/11/2014 Desloratadine (DS) is a tricyclic antihistaminic, characterized by bitter taste and slight water solubility. The aim of this study is to prepare DS as orally disintegrating tablets (ODT) to mask the bitter taste and improve compliance. Twelve different placebo ODT (F1-F12) were p...
متن کاملLc-ms/ms Method for the Simultaneous Determination of Desloratadine and Its Metabolite 3-hydroxy Desloratadine in Human Plasma
An accurate and highly sensitive LC-tandeem mass spectrometric method has been developed and validated for the quantification of desloratadine and its metabolite 3-hydroxy desloratadine according to regulatory guidelines. Following liquid–liquid extration analytes and internal standards (ISs) were extracted from K3EDTA human plasma. Chromatographic separation was achieved on Kromasil C18column ...
متن کاملSynthesis of 3-hydroxy desloratadine, the hydroxyl metabolite of loratadine
The structure of a major active metabolite of the nonsedating antihistamine loratadine was confirmed by synthesis. The metabolite 3 was prepared from 3-methyl pyridine in twelve steps.
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ژورنال
عنوان ژورنال: Pharmaceutical Sciences
سال: 2020
ISSN: 1735-403X,2383-2886
DOI: 10.34172/ps.2020.59