Evidence does not support vitamin D for reducing respiratory infections, reviews conclude

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Review Vitamin D and respiratory infections

Vitamin D or 1,25-hydroxyvitamin D (1,25(OH)2 D) has a well-established role in calcium homeostasis. In recent years, the discovery of vitamin D-metabolizing enzymes and vitamin D receptor (VDR) in the lungs and various cells of the immune system has led to numerous studies conducted to evaluate its role in respiratory functions and, in particular, upper respiratory tract infections (URTIs). A ...

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Children who spend more time outdoors are less likely to become myopic. One possible mechanism is that time outdoors prevents myopia because bright visible light increases retinal dopamine release, which inhibits axial elongation. This hypothesis has substantial support from animal experimentation. It has been proposed alternatively that exposure to ultraviolet (UV) light outdoors prevents myop...

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Vitamin D and respiratory tract infections in childhood

BACKGROUND Respiratory tract infections (RTIs) remain among of the most important causes of morbidity and mortality among children. Several studies have associated vitamin D deficiency with an increased risk of RTIs, and vitamin D supplementation has been proposed as a possible preventive measure against RTIs in children. The main aim of this review is to summarize the current evidence from the...

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Asthma, allergy and respiratory infections: the vitamin D hypothesis.

The recent discovery that every tissue in the human body has vitamin D receptors and that vitamin D has pleiotropic effects has prompted an increased interest in this hormone. Vitamin D deficiency is widespread and on the increase. There is no consensus on the serum vitamin D levels to consider appropriate for global health, the cutoffs for its deficiency, or the doses to use for its supplement...

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Assessment of 24,25(OH)2D levels does not support FGF23-mediated catabolism of vitamin D metabolites

Progressive elevations of fibroblastic growth factor 23 (FGF23) in chronic kidney disease may reduce serum 25-hydroxyvitamin D (25(OH)) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) levels, via stimulation of 24-hydroxylase (Cyp24a1)-mediated catabolism of these vitamin D metabolites. To test this possibility, we measured serum concentrations of 24,25-dihydroxyvitamin D (24,25(OH)(2)D), a product ...

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ژورنال

عنوان ژورنال: BMJ

سال: 2020

ISSN: 1756-1833

DOI: 10.1136/bmj.m2629