Evidence for a functional link between Dd-STATa and Dd-PIAS, a Dictyostelium PIAS homologue
نویسندگان
چکیده
منابع مشابه
Dd-STATa is a structural and functional homologue of the metazoan STAT (Signal Transducer and Activator
Dictyostelium discoideum cells form a multicellular organism by the chemotactic aggregation of up to 105 cells in response to extracellular cyclic AMP (cAMP) (Firtel, 1995; Chen et al., 1996). Upon aggregate formation, cells adopt one of two presumptive cell fates: approximately one-fifth differentiate into prestalk cells and the remainder into prespore cells (Firtel, 1995; Williams, 1995). Thr...
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Dd-STATa, a Dictyostelium discoideum homologue of metazoan STAT transcription factors, is necessary for culmination. We created a mutant strain with partial Dd-STATa activity and used it to screen for unlinked suppressor genes. We screened approximately 450,000 clones from a slug-stage cDNA library for their ability to rescue the culmination defect when overexpressed. There were 12 multicopy su...
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A Dd-STATa-null mutant, which is defective in expression of a Dictyostelium homologue of the metazoan STAT (signal transducers and activators of transcription) proteins, fails to culminate and this phenotype correlates with the loss of expression of various prestalk (pst) genes. An EST clone, SSK395, encodes a close homologue of the adducin amino-terminal head domain and harbors a putative acti...
متن کاملEvidence that the Dictyostelium Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for efficient chemotaxis.
Dd-STATa is a structural and functional homologue of the metazoan STAT (Signal Transducer and Activator of Transcription) proteins. We show that Dd-STATa null cells exhibit several distinct developmental phenotypes. The aggregation of Dd-STATa null cells is delayed and they chemotax slowly to a cyclic AMP source, suggesting a role for Dd-STATa in these early processes. In Dd-STATa null strains,...
متن کاملIdentification of new modes of Dd-STATa regulation of gene expression in Dictyostelium by in situ hybridisation.
Signal Transducers and Activators of Transcription (STATs) are transcription factors which lie at the end of cytokine and growth signal transduction pathways. Dictyostelium Dd-STATa is a functional homologue of metazoan STATs. It is activated by cAMP and, at the slug stage, it translocates into the nuclei of the tip cells, which are a subset of the anterior, prestalk A (pstA) cells. Here we sea...
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ژورنال
عنوان ژورنال: Development, Growth & Differentiation
سال: 2011
ISSN: 0012-1592
DOI: 10.1111/j.1440-169x.2011.01296.x