Evolution of Treatment Strategies for Calciphylaxis

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Cinacalcet for the treatment of calciphylaxis.

Calciphylaxis is characterized by cutaneous ischemia and necrosis and is associated with a very high mortality rate. It usually affects patients who are undergoing dialysis or who have received a kidney transplant. There is no optimal treatment, but parathyroidectomy has shown some benefit. We report herein a case of a patient with calciphylaxis and secondary hyperparathyroidism who was success...

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Simulation-based sodium thiosulfate dosing strategies for the treatment of calciphylaxis.

BACKGROUND AND OBJECTIVES Calciphylaxis remains a poorly understood life-threatening disorder with limited therapeutic options. Sodium thiosulfate (STS) has reported efficacy, thought to be because solubilizing calcium deposits promote clearance by hemodialysis (HD). Lack of rigorous pharmacokinetic studies makes it problematic for determining proper STS dosing given the expanding range of dial...

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ژورنال

عنوان ژورنال: American Journal of Nephrology

سال: 2011

ISSN: 1421-9670,0250-8095

DOI: 10.1159/000332221