Evolutionary Capacitance and Control of Protein Stability in Protein-Protein Interaction Networks
نویسندگان
چکیده
منابع مشابه
Evolutionary Capacitance and Control of Protein Stability in Protein-Protein Interaction Networks
In addition to their biological function, protein complexes reduce the exposure of the constituent proteins to the risk of undesired oligomerization by reducing the concentration of the free monomeric state. We interpret this reduced risk as a stabilization of the functional state of the protein. We estimate that protein-protein interactions can account for ~2-4 k(B)T of additional stabilizatio...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2013
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1003023