Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma

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Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma.

BACKGROUND Respiratory function and airway inflammation can be evaluated in preschool children with special techniques, but their relative power in identifying young children with asthma has not been studied. This study was undertaken to compare the value of exhaled nitric oxide (FE(NO)), baseline lung function, and bronchodilator responsiveness in identifying children with newly detected proba...

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Exhaled Nitric Oxide in Children with Asthma

1. Kharatonov SA, Barnes PJ. Exhaled markers of pulmonary disease. Am J Respir Crit Care Med. 2001;163:16931722. 2. Jouaville LF, Annesi-Maesano I, Nguyen LT, Bocage AS, Bedu M, Caillaud D. Interrelationship among asthma, atopy, rhinitis and exhaled nitric oxide in a populationbased sample of children. Clin Exp Allergy. 2003;33: 1506-11. 3. Wenzel SE. Asthma: defining of the persistent adult ph...

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EXHALED MARKERS Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission

Background: Nitric oxide in exhaled air (FENO) is a marker of eosinophilic airway inflammation. A study was undertaken to determine whether FENO predicts asthma relapse in asymptomatic asthmatic children in whom inhaled corticosteroids are discontinued. Methods: Forty children (21 boys) of mean age 12.2 years on a median dose of 400 mg budesonide or equivalent (range 100–400) were included. FEN...

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NO kidding: exhaled nitric oxide fraction in preschool children.

Wheeze is one of the most prevalent symptoms in preschool children with huge impacts on children and their families, on healthcare utilisation and hence costs [1]. While most children will become asymptomatic by 5–6 years of age, some will develop asthma or, even more importantly, severe problematic asthma and/or will experience an accelerated decline in lung function. Several studies have show...

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Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE.

RATIONALE For clinicians it remains very difficult to predict whether preschool children with symptoms suggestive of asthma will develop asthma in later childhood. OBJECTIVE To investigate whether measurement of fraction of exhaled nitric oxide (FE(NO)), interrupter resistance (Rint) or specific immunoglobulin E (IgE) in 4-year-old children with suggestive symptoms can predict asthma symptoms...

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ژورنال

عنوان ژورنال: Thorax

سال: 2003

ISSN: 0040-6376

DOI: 10.1136/thorax.58.6.494