Existence of Distinct GB Virus C/Hepatitis G Virus Variants with Different Tropism

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Existence of distinct GB virus C/hepatitis G virus variants with different tropism.

To study the existence of GB virus C/hepatitis G virus (GBV-C/HGV) variants with different tropism, we have analyzed the heterogeneity and quasispecies composition of GBV-C/HGV isolated from in vitro-infected peripheral blood mononuclear cells (PBMC) and from sera, livers, and PBMC from two chronically infected patients. For this purpose, the GBV-C/HGV 5' noncoding region (5'NCR) was amplified ...

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GB virus C/hepatitis G virus infection in southern China.

The prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection among intravenous drug users (IVDUs), patients with liver diseases, and blood donors in Nanning, southern China was studied. GBV-C/HGV RNA was detected by reverse transcription polymerase chain reaction with primers derived from the 5'-untranslated region. GBV-C/HGV RNA was detected in 64 of 85 IVDUs, 20 of 80 persons with liv...

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Homologous recombination in GB virus C/hepatitis G virus.

Analysis of 33 GB virus C/hepatitis G virus (GBV-C/HGV) full or nearly full genome sequences revealed several putative inter- and intrasubtype recombinants. The breakpoints of the recombinant regions were mapped using a maximum-likelihood method, and the statistical significance for each region was tested using Monte Carlo simulation. The results were highly significant and provided evidence fo...

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The entire nucleotide sequences of two GB virus C/hepatitis G virus isolates of distinct genotypes from Japan.

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 2000

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.74.17.7936-7942.2000