EXPANDS: expanding ploidy and allele frequency on nested subpopulations

EXPANDS: expanding ploidy and allele frequency on nested subpopulations

MOTIVATION Several cancer types consist of multiple genetically and phenotypically distinct subpopulations. The underlying mechanism for this intra-tumoral heterogeneity can be explained by the clonal evolution model, whereby growth advantageous mutations cause the expansion of cancer cell subclones. The recurrent phenotype of many cancers may be a consequence of these coexisting subpopulations...

What Expands in an Expanding Universe?

In the present investigation, the possible effects of the expansion of the Universe on systems bonded either by gravitational or electromagnetic forces, are reconsidered. It will be shown that the acceleration (positive or negative) of the expanding background, is the determinant factor affecting planetary orbits and atomic sizes. In the presently accepted cosmology (ΛCDM) all bonded systems ar...

Genotype and allele frequency of CYP2C19*17 in a healthy Iranian population

  Background: Cytochrome P450 2C19 (CYP2C19) is important in metabolism of wide range of drugs. CYP2C19*17 is a novel variant allele which increases gene transcription and therefore results in ultra-rapid metabolizer phenotype (URM). Distribution of this variant allele has not been well studied worldwide. The aim of present study was to investigate allele and genotype frequencies of CYP2C19*17 ...

Expanding the Message Passing Library Model with Nested Parallelism

A synchronous extension to the library model for message passing (Inmos C, PVM, Parmacs, MPI, etc.) is presented. This extension, provides a comfortable expression of nested parallelism from inside the message passing model. Furthermore of being a valuable tool for the presentation and teaching of parallel algorithms, the computational results prove that an efficiency similar to or even better ...

On the estimation of population size from allele frequency changes.