Expedient Synthesis of Electronically Modified Luciferins for Bioluminescence Imaging
نویسندگان
چکیده
منابع مشابه
Pushing The Boundaries of Bioluminescence Using Synthetic Luciferins: A Dissertation
Fireflies are beetles that generate yellow-green light when their luciferase enzyme activates and oxidizes its substrate, D-luciferin. This bioluminescent reaction is widely used as a sensitive reporter both in vitro and in vivo. However, the light-emitting chemistry is limited by the properties of the small molecule Dluciferin. Our lab has developed a panel of synthetic luciferin analogs that ...
متن کاملStereo-specificity and firefly bioluminescence, a comparison of natural and synthetic luciferins.
t Supported by Post-doctoral fellowship No. GF-7617-C2 from the Division of General Medical Sciences of the U.S. Public Health Service. l Levinthal, C., these PROCEEDINGS, 42, 394 (1956). 2 Levinthal, C., and C. A. Thomas, Biochim. et Biophys. A ta, 23, 453 (1957). 3Thomas, C. A., J. Gen. Physiol., 42, 503 (1959). 4 Mesels n, M., F. W. Stahl, and J. Vinograd, these PROCEEDINGS, 43, 581 (1957). ...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2012
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja301493d