Experimental animal models of cerebral ischemia
نویسندگان
چکیده
منابع مشابه
Animal models of cerebral ischemia for evaluation of drugs.
Stroke is a major cause of death and disability worldwide. The resulting burden on the society continues to grow, with increase in the incidence of stroke. Brain attack is a term introduced to describe the acute presentation of stroke, which emphasizes the need for urgent action to remedy the situation. Though a large number of therapeutic agents like thrombolytics, NMDA receptor antagonists, c...
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Combination therapy has been identified as a promising strategy to improve stroke management. We conducted a systematic review and meta-analysis of evidence from animal models of ischemic stroke to determine whether combining treatments improved efficacy. Multiple databases were searched and data were extracted from focal ischemia experiments comparing control groups, single treatments, and com...
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Animal models of stroke provide an essential tool for the understanding of the complex cellular and molecular pathophysiology of stroke and for testing novel recanalyzing, neuroprotective, neuroregenerative or anti- inflammatory drugs in pre- clinical setting. Since the first description of the distal occlusion of the middle cerebral artery (MCA) in rats, different techniques and methods to ind...
متن کاملAnimal models of focal and global cerebral ischemia.
The use of appropriate animal models is essential to predict the value and effect of therapeutic approaches in human subjects. Focal (stroke) and global (cardiac arrest) cerebral ischemia represents diseases that are common in the human population. Stroke and cardiac arrest, which are major causes of death and disability, affect millions of individuals around the world and are responsible for t...
متن کاملAnimal Models of Retinal Ischemia
Retinal ischemia is a frequent source of irreparable visual impairment and even loss of sight, affecting over a hundred million individuals in the world. It is associated with a wide range of clinical retinal disorders, like ischemic optic neuropathies, obstructive retinopathies, carotid occlusive disorders, diabetic retinopathy and glaucoma. Retinal ischemia occurs when the blood supply to ret...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)40286-2