Experimental Studies on ACTH Secretion Mechanism
نویسندگان
چکیده
منابع مشابه
Studies on the Mechanism of Experimental Proteinuria
When renin is administered intramuscularly to the rat, massive proteinuria occurs without a significant elevation of mean arterial blood pressure. The intravenous administration of renin to normal rats results in a great increase in urinary protein excretion. This response to renin is abolished by bilateral adrenalectomy. While the adrenalectomized rat fails to respond to intravenous renin with...
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It was found that ACTH greatly reduced lipogenesis in fat cells in the presence of calcium ion, but not in the absence of calcium ion. Of the enzymes involved in triglyceride synthesis from fatty acid in lipid micelle membranes, only acyl-CoA synthetase was inhibited by calcium ion, the apparent Ki value of calcium ion being 4.2 X 10(-4) M. The Km values of the enzyme for palmitate and ATP were...
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IN PREVIOUS investigations we have shown that the renin content of the blood and of the kidneys of patients with hypertension and of dogs with chronic hypertension due to renal ischemia is similar to that found in controls of both species.1-3 Clamping of the renal artery brings about a rapid increase within the first 20 minutes in the amount of renin in the kidney. This usually reaches a peak w...
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Human onchocerciasis is a debilitating disease, which causes lymphatic obstruction and gives rise to genital elephantiasis. The microfilariae also cause severe itching, while invasion of the eyes by large numbers, and the reaction to their presence, lead to river blindness. This results in severe medical, social and economic problems (Stevenson 1987).The implications of the disease bring about ...
متن کاملStudies on the Mechanism of Experimental Proteinuria Induced by Renin
Renin-induced proteinuria in the rat was investigated, with special emphasis on the relationship between the enzymatic activity and the proteinuric effect of renin. The dependence of the proteinuric effect on the enzymatic activity was shown by using (a) renin preparations of widely varying purity and (b) chemically modified "active" and "inactive" renin derivatives. Angiotensin II, the pressor...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1968
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.44.9_1056