Exploring novel secondary metabolites from natural products using pre-processed mass spectral data

Bioactive natural products from fungicolous Hawaiian isolates: secondary metabolites from a Phialemoniopsis sp.

Chemical investigations of two fungal isolates initially identified as members of the genus Phialemonium are described. Both isolates were obtained as colonists of other fungi collected on the island of Hawaii and were later assigned as P. curvatum. However, P. curvatum has recently been reclassified as a member of a new genus (Phialemoniopsis) and renamed as Phialemoniopsis curvata. Studies of...

Natural products: Hunting microbial metabolites.

Novel Secondary Metabolites from Endophytic Marine-derived Fungi

The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia cf. C. flammea. Chemical investigation of the bioactive fungal extract led to the isolation of the novel phthalimidine derivatives marilines A D (1-4). The absolute configuration of the enantiomeric compounds 1 and 2 was assigned by means of theoretical Circular Dichroism calculations. The skeleton of marilines...

Novel delivery system for natural products: Nano-curcumin formulations

Objective: Curcumin is extracted from Curcuma longa and regulates the intracellular signal pathways which control the growth of cancerous cell, inflammation, invasion and apoptosis. Curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (DNA) and messengers (RNA). A wide range of studies have been conducted on the physicochemical traits and pharmaco...

Secondary metabolites from the roots of Astragalus maximus

Background and objectives: Astragalus is one of the most abundant genera of flowering plants in Iran. There are a few reports on phytochemical investigation of this valuable genus. Saponins, flavonoids and polysaccharides have been reported as the most important metabolites in Astragalus species. In the present research, we aimed to identify the foremost const...