Exposing Hidden Conformations of Carbamazepine Appearing Due to Interaction With the Solid Phase by 2D 1H-15N HMBC NMR Spectroscopy
نویسندگان
چکیده
Two-dimensional 1H-15N HMBC NMR spectra of the well-known anticonvulsant carbamazepine dissolved in different organic solvents, recorded on an spectrometer prove existence hidden conformers saturated solutions. Obtained conformer distribution arises due to presence solid phase solution. A weak influence ring currents was revealed for molecular conformations a solution, which provides simple approach discovering conformations. Hidden were found three solvents: dimethyl sulfoxide, chloroform, and dichloromethane.
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2021
ISSN: ['0022-3549', '1520-6017']
DOI: https://doi.org/10.1016/j.xphs.2021.01.001