Exposure to ethylene glycol ethers and spermatogenic disorders in man: a case-control study.
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چکیده
منابع مشابه
Exposure to ethylene glycol ethers and spermatogenic disorders in man: a case-control study.
A case-control study was conducted among first time patients at a clinic for reproductive disorders. The study group consisted of 1019 cases, defined as patients diagnosed infertile or subfertile on the basis of a spermiogram and 475 controls who were diagnosed as normally fertile by the same procedure. Possible exposure to ethylene glycol ethers was assessed by the presence of the urinary meta...
متن کاملInteractive effect of combined exposure to ethylene glycol ethers and ethanol on hematological parameters in rats
The study of the interaction of three glycol ethers, i.e. 2-methoxyethanol (ME), 2-ethoxyethanol (EE) and 2-butoxyethanol (BE) administered subcutaneously for 4 weeks and ethanol simultaneously given as 10% w/v solution for drinking in male rats, was carried out from a toxicodynamic point of view. Administered alone, ME (2.5 and 5.0 mM/kg), EE (2.5 and 5.0 mM/kg) or BE (0.75 and 1.25 mM/kg) res...
متن کاملUrinary alkoxyacetic acids and renal effects of exposure to ethylene glycol ethers.
OBJECTIVES Ethylene glycol ethers and their acetates are widely used in industry, because of their hydrophilic and simultaneously lipophilic properties. Ethylene glycol ethers and their acetates are mainly metabolised to alkoxyacetic acids, but there is also a minor pathway through ethylene glycol to oxalic acid. The main pathway of ethylene glycol ethers is associated with significant clinical...
متن کاملHematological effects of exposure to mixtures of selected ethylene glycol alkyl ethers in rats.
Exposure to various ethylene glycol monoalkyl ethers (EGAEs) is known to result in hemolytic effect caused by their metabolites, appropriate alkoxyacetic acids, generated via both alcohol dehydrogenase and aldehyde dehydrogenase. It has been shown in many studies that administration of single doses of EGAEs to rats lead to dose- and time-dependent hemolytic anemia. The repeated exposure to isop...
متن کاملEthylene glycol ethers and risks of spontaneous abortion and subfertility.
Potential reproductive effects from occupational exposures to ethylene glycol ethers (EGE) are of concern since these organic solvents have been used widely in industry, and their reproductive toxicity has been well documented in animal studies. For determination of whether occupational exposure to EGE was associated with increased risks of spontaneous abortion and subfertility (i.e., taking mo...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1993
ISSN: 1351-0711
DOI: 10.1136/oem.50.1.71