Expression and functions of cellular prion proteins in immunocytes
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چکیده
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Physiological Functions of the Cellular Prion Protein
The prion protein, PrPC, is a small, cell-surface glycoprotein notable primarily for its critical role in pathogenesis of the neurodegenerative disorders known as prion diseases. A hallmark of prion diseases is the conversion of PrPC into an abnormally folded isoform, which provides a template for further pathogenic conversion of PrPC, allowing disease to spread from cell to cell and, in some c...
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Cellular prion (PrPc) is a plasma membrane glycosyphosphatidylinositol-anchored protein present in neurons but also in other cell types. Protein conservation among species suggests that PrPc may have important physiological roles. Cellular and molecular approaches have established several novel features of the regulation of PrPc expression, cellular trafficking as well as its participation in c...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2019
ISSN: 0300-9475,1365-3083
DOI: 10.1111/sji.12854