Expression Regulation of Major Histocompatibility Complex Class I and Class II Encoding Genes
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چکیده
منابع مشابه
Expression Regulation of Major Histocompatibility Complex Class I and Class II Encoding Genes
Major histocompatibility complex (MHC)-I and MHC-II molecules play an essential role in the immune response to pathogens by virtue of their ability to present peptides to CD8⁺ and CD4⁺ T cells, respectively. Given this critical role, MHC-I and MHC-II genes are regulated in a tight fashion at the transcriptional level by a variety of transcription factors that interact with conserved cis-acting ...
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Major histocompatibility complex (MHC) class I and class II molecules bind to and display peptidic antigens acquired from pathogens that are recognized by lymphocytes coordinating and executing adaptive immune responses. The two classes of MHC proteins have nearly identical tertiary structures and were derived from a common ancestor that probably existed not long before the emergence of the car...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2011
ISSN: 1664-3224
DOI: 10.3389/fimmu.2011.00048