Extent of correlation between first and second trimester markers for Down's syndrome screening
نویسندگان
چکیده
منابع مشابه
Combining first and second trimester markers for Down syndrome screening: think twice.
AIMS This study compares different screening strategies for the detection of Down syndrome and considers practical implications of using multiple screening protocols. METHODS The performance characteristics of each screening strategy were assessed based on datasets of Down syndrome (n=11) and unaffected pregnancies (n=1006) tested in both first and second trimester, as well as data from first...
متن کاملFirst-trimester or second-trimester screening, or both, for Down's syndrome.
BACKGROUND It is uncertain how best to screen pregnant women for the presence of fetal Down's syndrome: to perform first-trimester screening, to perform second-trimester screening, or to use strategies incorporating measurements in both trimesters. METHODS Women with singleton pregnancies underwent first-trimester combined screening (measurement of nuchal translucency, pregnancy-associated pl...
متن کاملFirst-trimester screening for Down's syndrome.
The aim of the present study was to evaluate the efficacy of the first trimester screening for Down syndrome (DS) in an unselected low-risk Finnish population. The study involved 4,617 women who attended screening between the 8th and 14th weeks of pregnancy in 1998-2000. They gave a blood sample for the measurement of pregnancy associated plasma protein A (PAPP-A) and free beta human chorionic ...
متن کاملScreening for Down's syndrome: effects, safety, and cost effectiveness of first and second trimester strategies.
OBJECTIVE To compare the effects, safety, and cost effectiveness of antenatal screening strategies for Down's syndrome. DESIGN Analysis of incremental cost effectiveness. SETTING United Kingdom. MAIN OUTCOME MEASURES Number of liveborn babies with Down's syndrome, miscarriages due to chorionic villus sampling or amniocentesis, health care costs of screening programme, and additional costs...
متن کاملFirst- and second-trimester evaluation of risk for Down syndrome.
OBJECTIVE To investigate the differences in costs and outcomes of Down syndrome screening using data from the First and Second Trimester Evaluation of Risk (FASTER) Trial. METHODS Seven possible screening options for Down syndrome were compared: 1) Triple Screen-maternal serum alpha fetoprotein, estriol, and hCG; 2) Quad-maternal serum alpha fetoprotein, estriol, hCG, and Inhibin A; 3) Combin...
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ژورنال
عنوان ژورنال: Journal of Medical Screening
سال: 2000
ISSN: 0969-1413,1475-5793
DOI: 10.1136/jms.7.3.163