Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction

Congenital vaginal anomalies and pelvic organ prolapse affect different age groups of women both have significant negative impacts on patients’ psychological well-being quality life. While surgical non-surgical treatments are available for defects, their efficacy is limited, they often result in long-term complications. Therefore, alternative treatment options urgently needed. Fortunately, tissue-engineered scaffolds promising new modalities that provide an extracellular matrix (ECM)-like environment cells to adhere, secrete ECM, be remodeled by host cells. To this end, ECM-based or the constructs resemble generated self-assembly, decellularization, electrospinning techniques, gained attention from clinicians researchers. These biomimetic highly similar native ECM great potential clinical translation. This review article aims discuss recent applications, challenges, future perspectives these reconstruction repair strategies.