F1-02-02: NFκB and complement C3 mediated neuron-glia interaction in neuronal health and Alzheimer's disease
نویسندگان
چکیده
منابع مشابه
NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease
Abnormal NFκB activation has been implicated in Alzheimer's disease (AD). However, the signaling pathways governing NFκB regulation and function in the brain are poorly understood. We identify complement protein C3 as an astroglial target of NFκB and show that C3 release acts through neuronal C3aR to disrupt dendritic morphology and network function. Exposure to Aβ activates astroglial NFκB and...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2015
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2015.07.011