Facile Synthesis of 5,6,7,8-tetrahydropyrimido[4,5-d] pyrimidine-2,4 (1H,3H) -dione Analogs via One Pot Multicomponent Reaction
نویسندگان
چکیده
منابع مشابه
Facile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in Ionic Liquid and study of their antibacterial activities
A simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIm]Br) under solvent-free conditions is reported. The presented method is benefited from operational simplicity...
متن کاملFacile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in Ionic Liquid and study of their antibacterial activities
A simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIm]Br) under solvent-free conditions is reported. The presented method is benefited from operational simplicity...
متن کاملA facile one-pot synthesis of thiazoles and thiazolyl-pyrazole derivatives via multicomponent approach
Thiazoles and thiazolyl-pyrazole derivatives have been efficiently synthesized under neat reaction conditions in excellent yields. Condensation of 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one (1), thiosemicarbazide (2) and various carbonyl compounds (3 & 5) gave corresponding thiazole (4) and thiazolylpyrazole derivatives (6) in excellent yields by using Hantzsch-Thiazole synthesis. The ...
متن کاملOne-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar
phenytoine derivatives were synthesized , via the pinacol condensation with the reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea in presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle at room temperatures. The reaction was completed at short reaction times (approximately 15min) and pure products were obtained with high yie...
متن کاملOne-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar
phenytoine derivatives were synthesized , via the pinacol condensation with the reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea in presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle at room temperatures. The reaction was completed at short reaction times (approximately 15min) and pure products were obtained with high yiel...
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ژورنال
عنوان ژورنال: FRONTIERS IN CHEMICAL SCIENCES
سال: 2020
ISSN: 2707-6024
DOI: 10.52700/fcs.v1i1.2