FAS system deregulation in T-cell lymphoblastic lymphoma
نویسندگان
چکیده
منابع مشابه
T-cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma
T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LL) are neoplasias of immature T-cell precursors considered as a unique biological entity in the 2008 World Health Organization Classification of Hematologic Neoplasias1. Both entities are arbitrarily separated by a cut-off point of 20%-25% of blast cells in the bone marrow. There is a general agreement that T-ALL ...
متن کاملT-lymphoblastic leukemia/lymphoma.
OBJECTIVES To review important concepts from the 2013 Society for Hematopathology/European Association for Haematopathology Workshop session on T-acute lymphoblastic leukemia/T-lymphoblastic lymphoma (T-ALL/T-LBL). METHODS Twenty-one submitted cases are reviewed and summarized, with emphasis on key diagnostic or biologic points, and supplemented with relevant literature citations. RESULTS E...
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Background and aim: Adult T cell leukemia/lymphoma (ATLL) is an aggresive malignancy which may occur in human T lymphotropic virus1(HTLV1) infected persons. HTLV1 is endemic in Khorasan with prevalence of 2.3% in general population. Since specific cutaneous manifestations of lymphoma may occur in a significant number of patients, we studied ATLL patients in Mashhad.Mate...
متن کاملImmune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma
We describe the case of a 13-year-old boy who presented with persistent thrombocytopenia during maintenance chemotherapy with mercaptopurine and methotrexate for T cell lymphoblastic lymphoma. He was diagnosed with immune thrombocytopenia (ITP) after thorough investigations for the relapse of lymphoma and was successfully treated with immunoglobulin and steroids. ITP is known to be associated w...
متن کاملDeregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma
In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor aggressiveness. The resultant balance between FADD-dependent apoptotic and non-apoptotic abiliti...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2014
ISSN: 2041-4889
DOI: 10.1038/cddis.2014.83