Fast and insightful bi-objective optimization for prostate cancer treatment planning with high-dose-rate brachytherapy

High dose rate brachytherapy for prostate cancer.

High dose rate (HDR) afterloading brachytherapy in the management of localised prostate cancer has practical, physical and biological advantages over low dose rate seed brachytherapy. There are no free live sources used, no risk of source loss and since the implant is a temporary procedure following discharge no issues with regard to radioprotection use of existing facilities. Adequate coverage...

High-dose-rate Brachytherapy for Prostate Cancer

Introduction/Background Over the last 2 decades, significant technical advancements have improved the delivery of prostate brachytherapy. The transrectal ultrasound-guided implant technique is the backbone of modern prostate brachytherapy. Whether it is permanent or temporary, ie, low-dose-rate (LDR) or high-dose-rate (HDR), respectively, both use similar image-guided techniques for inserting s...

Application and benchmarking of multi-objective evolutionary algorithms on high-dose-rate brachytherapy planning for prostate cancer treatment

High-Dose-Rate (HDR) brachytherapy (BT) treatment planning involves determining an appropriate schedule of a radiation source moving through a patient’s body such that target volumes are irradiated with the planning-aim dose as much as possible while healthy tissues (i.e., organs at risk) should not be irradiated more than certain thresholds. Such movement of a radiation source can be defined b...

High-dose-rate Brachytherapy for Prostate

Low-dose-rate or high-dose-rate brachytherapy in treatment of prostate cancer – between options

PURPOSE Permanent low-dose-rate (LDR-BT) and temporary high-dose-rate (HDR-BT) brachytherapy are competitive techniques for clinically localized prostate radiotherapy. Although a randomized trial will likely never to be conducted comparing these two forms of brachytherapy, a comparative analysis proves useful in understanding some of their intrinsic differences, several of which could be exploi...