FAT is a component of glomerular slit diaphragms
نویسندگان
چکیده
منابع مشابه
The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium
The foot processes of glomerular epithelial cells of the mammalian kidney are firmly attached to one another by shallow intercellular junctions or slit diaphragms of unknown composition. We have investigated the molecular nature of these junctions using an antibody that recognizes ZO-1, a protein that is specific for the tight junction or zonula occludens. By immunoblotting the affinity purifie...
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Glomerular visceral epithelial cells (podocytes) contain interdigitated processes that form specialized intercellular junctions, termed slit diaphragms, which provide a selective filtration barrier in the renal glomerulus. Analyses of disease-causing mutations in familial nephrotic syndromes and targeted mutagenesis in mice have revealed critical roles of several proteins in the assembly of sli...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2001
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2001.0590031003.x