Fatal postlymphoma chemotherapy hepatitis B reactivation secondary to the emergence of a YMDD mutant strain with lamivudine resistance in a noncirrhotic patient
نویسندگان
چکیده
منابع مشابه
hepatitis b virus ymdd-motif mutations with emergence of lamivudine-resistant mutants: a threat to recovery
hepatitis b virus (hbv) is a crucial public health problem with approximately 350 million affected people and a death rate of 0.5 to 1.2 million per year worldwide. it proceeds to end-stage liver diseases including cirrhosis with hepatic decompensation and hepatocellular carcinoma (hcc). pakistan lies in the endemic region with 3% hbv carrier rate in the country. the differences in disease outc...
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virus surface antigen (HBsAg) is known to promote viral replication, and when immunosuppressive treatment is stopped the return of immunocompetence can be followed by liver damage of varying degrees of severity, including fulminant hepatitis. Hepatitis B virus (HBV) reactivation of various degrees may develop in 20-50% of HBsAg positive patients undergoing immunosuppressive or cytostatic treatm...
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A high incidence of HBV-related hepatitis is associated with the use of HBsAg-positive marrow for transplantation, and the high viral load in the donor appears to predispose recipients to the development of HBV-related hepatitis postransplant. Preemptive use of lamivudine has proved to reduce hepatitis B exacerbation in HBsAgpositive recipients of allogeneic HCT. Since 2000, the policy in our m...
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We previously developed a method of detecting drug-resistant mutation of hepatitis B virus (tyrosine (Y)-methionine (M)-aspartic acid (D)-aspartic acid (D) (YMDD) mutation) caused by the antiviral agent lamivudine. Using this method, we also reported that YMDD mutation is present in asymptomatic carriers that had not been administered antiviral agents. Thus, we investigated the clinical charact...
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Hepatitis B virus (HBV) reactivation during chemotherapy is a major concern and is widely reported, particularly in association with hematological malignancies and lymphomas. While lung cancer ranks first in incidence and mortality worldwide, HBV reactivation has been largely overlooked in this disease. As regards small-cell lung cancer (SCLC), HBV reactivation has rarely been reported. We here...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2006
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.20737