FcRn in the Yolk Sac Endoderm of Mouse Is Required for IgG Transport to Fetus
نویسندگان
چکیده
منابع مشابه
FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus.
In adults, the nonclassical MHC class I molecule, FcRn, binds both IgG and albumin and rescues both from a degradative fate, endowing both proteins with high plasma concentrations. FcRn also transports IgG from mother to young during gestation. Anticipating that a detailed understanding of gestational IgG transport in the mouse may give us a useful model to understand FcRn function in the human...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2009
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.0803247