Features to validate cerebral toxoplasmosis

Features to validate cerebral toxoplasmosis.

INTRODUCTION Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics. METHODS We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics. RESULTS In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplas...

Immunopathogenesis of cerebral toxoplasmosis.

Interferon (IFN)-gamma is an absolute requirement for resistance against acute acquired infection with Toxoplasma gondii and development of toxoplasmic encephalitis (TE) during the late stage of infection. Multiple populations of both T and non-T cells are important sources of IFN-gamma in resistance. In the absence of IFN-gamma-producing non-T cells, T cells cannot prevent TE. Interleukin-12, ...

Ly6C Monocytes Control Cerebral Toxoplasmosis

Clinical and prognostic features of cerebral toxoplasmosis in HIV infected patients – a case series

Results Cerebral toxoplasmosis led to the diagnosis of HIV infection in 3/11 patients, and was the AIDS defining disease in 2/11 cases. Most of the patients (9/11) belonged to the historical 1989 cohort; the mean age was 22.5 years, 6/11 were males. The mean CD4+ cell count was 26.7 cells/cmm (95%CI: 5.5-49.7); all the patients were viremic at the time of diagnosis (mean viral load: 1.21x10 cop...

Cerebral toxoplasmosis requiring urgent brain biopsy

A 39-yerar-old man was admitted to our hospital with behavioral disturbances and generalized headaches. He was diagnosed with CNS toxoplasmosis after performing a brain biopsy. He found to be HIV positive with a CD4 of 14/uL He was started on ant toxoplasmosis along with antiretroviral therapy. He presented 6 weeks after discharge with worsening headache thought to be related to relapse of toxo...