Fetal Programming of Diabetes: Still So Much to Learn!

Fetal Programming of Diabetes: Still So Much to Learn!

Much to Learn! In the preinsulin era, pregnancy in a diabetic mother had a bleak outcome for both the mother and the baby. Availability of insulin and modern methods of treatment improved the survival of these babies, but they appear to be at increased risk of obesity and diabetes (1–3). Spread of the diabetes pandemic to the young means there is now a growing epidemic of gestational diabetes m...

Splicing: still so much to learn.

This issue marks the 20th year since the launching of RNA in March of 1995. It is a time to celebrate, as well as to consider the substantial accomplishments achieved in these two decades, both in the RNA field as a whole, and in the specific areas in which each of us works—in my case, human premRNA splicing mechanisms and regulation, and its relevance to human disease. Moreover, this is a time...

Lipoprotein (a)—We Know So Much Yet Still Have Much to Learn …

L ipoprotein(a) (Lp[a]) has been identified as an independent , causal risk factor for cardiovascular disease (CVD). 1,2 Lp(a) has a structure similar to low-density lipopro-tein (LDL) in its lipid core composition in addition to a molecule of apolipoprotein B 100 (apoB), but also contains a unique glycoprotein—apo(a), with strong structural homology with plasminogen. 2 Apo(a) contains anything...

Exercise induced asthma, still much to learn.

The health impact of German unification: still much to learn.

The division of Germany after the second world war has often been recognised as providing a unique opportunity to evaluate “a natural experiment in history”, one in which a homogenous population had been artificially separated for 45 years. The possible consequences for health of exposure to two very diVerent social models have, however, received relatively little attention. When the Berlin Wal...