Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant

CD 14 Is an Acute - Phase Protein 1

CD14 is an acute-phase protein.

The origin of soluble CD14 (sCD14) in the circulation is uncertain. To examine whether CD14 could be an acute-phase protein (APP), the levels of sCD14, IL-6, and C-reactive protein were determined by ELISA in serum and synovial fluid (SF) of patients with various arthropathies, and the regulation of CD14 synthesis was examined in liver cells. In patients with crystal-mediated or immunologically...

Identification of a lipid A binding site in the acute phase reactant lipopolysaccharide binding protein.

Lipopolysaccharide (LPS) binding protein (LBP), a recently discovered 60-kDa acute phase protein, is present in the acute phase serum of many species including human, rabbits, mice, and rats. Using either highly purified LBP from acute phase rabbit serum or unfractionated acute phase rabbit serum as a source of LBP, we examined the binding of LBP to LPS immobilized on plastic microtiter plates ...

Chronic concern over an acute-phase reactant: a teachable moment.

A59-year-oldmanwith a history of shoulder and knee pain presented to our clinic reporting 6 years of left osteoarthritic hippain.Hispainhadbeenprogressive, and at the timeofpresentation,he required theuseofacane for support. The results of radiologic studies showed a loss of joint space with thinning of the upper aspect of the lefthip jointwithbone-on-boneappearanceandsubchondral cyst formation...

Angiotensinogen: an acute-phase protein?

Angiotensinogen has been assumed to be an acute-phase protein, because some forms of acute inflammation, eg, the injection of lipopolysaccharide or cellite or partial hepatectomy, increased the hepatic synthesis of angiotensinogen. In addition, the well-characterized nephrectomy-induced stimulation of angiotensinogen was thought to represent an acute-phase reaction. To evaluate this hypothesis,...