Fibrinogen precursors. Order of assembly of fibrinogen chains.
نویسندگان
چکیده
منابع مشابه
The assembly of nonadhesive fibrinogen matrices depends on the αC regions of the fibrinogen molecule.
Adsorption of fibrinogen on fibrin clots and other surfaces strongly reduces integrin-mediated adhesion of platelets and leukocytes with implications for the surface-mediated control of thrombus growth and blood compatibility of biomaterials. The underlying mechanism of this process is surface-induced aggregation of fibrinogen, resulting in the assembly of a nanoscale multilayered matrix. The m...
متن کاملStructural organization of C-terminal parts of fibrinogen k-chains
There is a widespread opinion that about 400 residue-long C-terminal parts of both the AW chains in fibrinogen do not form a compact ordered structure since they are hydrolyzed too fast at treatment of the molecule by proteolytic enzymes [l]. However, our calorimetric study of fibrinogen melting and of its fragments have shown that parts of this molecule which are removed on the early stage of ...
متن کاملThe Role of Fibrinogen Aa Chains in ADP-tnduced Platelet Aggregation in the Presence of Fibrinogen Molecules Containing “y’Chains
Human plasma fibrinogen (Fgn) is heterogenous with respect to the size of its ‘y chains. which differ in that residues 408 to 41 1 of #{176}y chains (93% of total) are replaced in “y’ chains by a unique 20 amino acid sequence (#{176}y to #{176}y ). In this study. we compared the contribution to adenosine diphosphate (ADP)-induced platelet aggregation of the Aa chains in Fgn molecules containing...
متن کاملCharacterization of the inhibition of fibrin assembly by fibrinogen
Fragment D (M, 100000) prepared from a terminal plasmin digest of fibrinogen was isolated and used to study its effect on fibrin formation. Increasing amounts of fragment D added to a solution of fibrinogen and thrombin decrease the rigidity of the resultant gel (10% of control at 2mol of fragment D/mol of fibrinogen). Half-maximal inhibition is achieved at 1 mol of fragment D/mol of fibrinogen...
متن کاملStudies of platelet fibrinogen from a subject with a congenital plasma fibrinogen abnormality (fibrinogen Paris I).
Fibrinogen from normal platelets and plasma was compared with material derived from a subject with the congenital fibrinogen abnormality termed fibrinogen Paris I. The molecular abnormality in this subject is characterized by the presence (in plasma molecules) of relatively large mutant ‘y-chains (‘y-Paris I) that replace 50% or more of the normal “y-chain population and that, unlike normal ‘y-...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1984
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)91001-x