Fibroblast growth factor 21 as a biomarker for NAFLD: Integrating pathobiology into clinical practice
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چکیده
منابع مشابه
Fibroblast growth factor 21, a biomarker for mitochondrial muscle disease.
For many patients, a mitochondrial disease diagnosis is often difficult to establish with certainty, except in cases with a classical clinical presentation. Invasive and time-consuming methods, such as tissue biopsy and enzymatic studies, are frequently necessary before proceeding to molecular genetic analyses, because of the low specificity and sensitivity of existing lessinvasive biomarkers, ...
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BACKGROUND The finding of new biomarkers is needed to have a better sub-classification of primary renal tumors (RCC) as well as more reliable predictors of outcome and therapy response. In this study, we evaluated the role of circulating FGF21, an endocrine factor, as a diagnostic and prognostic biomarker for ccRCC. MATERIALS AND METHODS Serum samples from healthy controls (HC), clear cell an...
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Background: Basic fibroblast growth factor (bFGF) is a glycoprotein with stimulating ability of angiogenesis. In addition, bFGF plays an important role in wound healing process in some tissues for example gastrointestinal tract, but its ability for discrimination of various stages of wound severity in these diseases was not reported. Therefore, we aimed to determine the bFGF levels in gastric u...
متن کاملSerum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes.
OBJECTIVE Fibroblast growth factor 21 (FGF21) improves glucose and lipid metabolism, but high circulating levels are found in type 2 diabetes, suggesting FGF21 resistance. Serum FGF21 predicts incident diabetes, but its performance compared to established and emerging predictors is not known. We aimed to study the performance of FGF21 in diabetes prediction, relative to other adipokines and est...
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Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family. Acting in an endocrine fashion, it increases glucose uptake, modulates lipid metabolism, and sensitizes insulin response in metabolically active organs, including the liver and adipose tissue. Emerging evidence shows a strong correlation between circulating FGF21 levels and the incidence and severity of atherosclerosis...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2010
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2010.07.003