Fibroblast growth factor 21, ketogenic diets, and insulin resistance
نویسندگان
چکیده
منابع مشابه
The evaluation of Changes in Lipid Profiles, Insulin Resistance and Serum Fibroblast Growth Factor 21 Following Three Types of Exercise Training in Sedentary Obese Children
Aims: Obesity is associated with cardiovascular disease. Today, changing childhood lifestyle may affect on cardiovascular diseases factors. The goal of this research was to determine the evaluation of changes in lipid profiles, insulin resistance and serum FGF21 following three types of exercise training in sedentary obese children. Materials and Methods: Sixty obese boys 8-12 years old with z...
متن کاملFree Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21
OBJECTIVE Fibroblast growth factor (FGF)-21 improves insulin sensitivity and lipid metabolism in obese or diabetic animal models, while human studies revealed increased FGF-21 levels in obesity and type 2 diabetes. Given that FGF-21 has been suggested to be a peroxisome proliferator-activator receptor (PPAR) alpha-dependent regulator of fasting metabolism, we hypothesized that free fatty acids ...
متن کاملFibroblast growth factor 21 and exercise-induced hepatic mitochondrial adaptations.
Exercise stimulates hepatic mitochondrial adaptations; however, the mechanisms remain largely unknown. Here we tested whether FGF21 plays an obligatory role in exercise induced hepatic mitochondrial adaptations by testing exercise responses in FGF21 knockout mice. FGF21 knockout (FGF21-KO) and wild-type (WT) mice (11-12 wk of age) had access to voluntary running wheels for exercise (EX) or rema...
متن کاملFibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) Adipocytes
Fibroblast growth factor 21 (FGF21) has evolved as a major metabolic regulator, the pharmacological administration of which causes weight loss, insulin sensitivity and glucose control in rodents and humans. To understand the molecular mechanisms by which FGF21 exerts its metabolic effects, we developed a human in vitro model of adipocytes to examine crosstalk between FGF21 and insulin signaling...
متن کاملKetogenic diets and pain.
Ketogenic diets are well established as a successful anticonvulsant therapy. Based on overlap between mechanisms postulated to underlie pain and inflammation, and mechanisms postulated to underlie therapeutic effects of ketogenic diets, recent studies have explored the ability for ketogenic diets to reduce pain. Here we review clinical and basic research thus far exploring the impact of a ketog...
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ژورنال
عنوان ژورنال: American Journal of Clinical Nutrition
سال: 2011
ISSN: 0002-9165,1938-3207
DOI: 10.3945/ajcn.111.019646